Radiation and chemical activation of ras oncogenes in different mouse strains.

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Radiation and chemical activation of ras oncogenes in different mouse strains.

A survey of a large series of radiation- or chemically induced thymic lymphomas in (AKR X RF)F1, RF/J, 129/J, and C57BL/6J mouse strains for activated ras oncogenes showed that of the tumors containing transforming activity, in more than 75% of the cases this activity segregated with either K-ras or the N-ras gene. H-ras activity was never detected. The genetic background of the host influenced...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1989

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.898133